Already 2 microns is super small. As particle size decreases, the penetration efficiency into the lungs increases due to lower inertia. At some point, however, the particles are so small that brownian motion (= diffusion) dominates the depositon mechanism already before the particles reach the lungs. During my aerosol lectures, we learned that particles of around half a micron have the highest deposition rate into the lungs (see link below). I often hear people saying “the smaller the particles, the deeper they get into the lungs.” I am unaware of evidence to support this statement.
Personally, I am concerned about the mass of solid particles that reach my lungs and do not dissolve. In other words, I am worried about the mass of stuff in my lungs that accumulates and does not belong there. I am less worried about liquid particles or salt particles, as they may dissolve and do not (or less) accumulate.
On the other hand, I am concerned about ultrafine particles (= nanoparticles) reaching my lungs even if the mass is low. I am not necessarily concerned about my lung health, but more my general health as some of these particles likely enter my body and reach all organs with unknown implications. I normally measure 10’000 nanoparticles per mililiter of ambient “clean” air, but I have no clue where these particles come from. Neither do I know what they are or whether this number is just a normal natural background level or whether it is greatly polluted air. There is currently no clear evidence to say that these particles are a problem. Similarly, it is unclear whether they are not a problem. This field of research has just started to pick up momentum.
At the end of the day, we should not forget that particles at some point become atoms as they get smaller and smaller. Today’s instruments have lower size cut-offs of just a few nanometers - these particles are basically just a group of a few atoms. Are particles of that size a problem? Maybe not necessarily, but I assume it highly depends on what the particles are made from. There are definitely many research questions to be explored